Novel histamine H 3 receptor antagonists based on the 4-[(1H-imidazol-4-yl) methyl] piperidine scaffold

…, M Berlin, NY Shih, R Aslanian, JH Schwerdt…

文献索引：Vaccaro, Wayne D.; Sher, Rosy; Berlin, Michael; Shih, Neng-Yang; Aslanian, Robert; Schwerdt, John H.; McCormick, Kevin D.; Piwinski, John J.; West Jr., Robert E.; Anthes, John C.; Williams, Shirley M.; Wu, Ren-Long; She, H. Susan; Rivelli, Maria A.; Mutter, Jennifer C.; Corboz, Michel R.; Hey, John A.; Favreau, Leonard Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 395 - 399

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被引用次数: 8

摘要

We report the discovery of novel histamine H3 receptor antagonists based on 4-[(1H- imidazol-4-yl) methyl] piperidine. The most potent compounds in the series (eg, 7) result from the attachment of a substituted aniline amide to the main pharmacophore piperidine via a two-methylene linker.