Non-hydrolysable analogues of inorganic pyrophosphate as inhibitors of hepatitis C virus RNA-dependent RNA-polymerase

…, AN Korovina, NN Usanov, SN Kochetkov

文献索引：Yanvarev; Korovina; Usanov; Kochetkov Russian Journal of Bioorganic Chemistry, 2012 , vol. 38, # 2 p. 224 - 229

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被引用次数: 9

摘要

Abstract Inorganic pyrophosphate (PP i) is the product of the polymerization reaction catalyzed by DNA-and RNA-polymerases. A number of novel non-hydrolsable PP i analogues was synthesized; some of them inhibited the polymerization reaction catalyzed by hepatitis C virus RNA-dependent RNA-polymerase (NS5B). A new pharmacophore based on a non-hydrolysable methylenediphosphonate backbone has been developed. ...