Diastereoselectivity Control of the Radical Carboazidation of Substituted Methylenecyclohexanes

…, P Schär, P Renaud, K Schenk

文献索引：Cren, Sylvaine; Schar, Pascal; Renaud, Philippe; Schenk, Kurt Journal of Organic Chemistry, 2009 , vol. 74, # 8 p. 2942 - 2946

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被引用次数: 21

摘要

A systematic study of the diastereoselectivity of the radical carboazidation of methylenecyclohexane derivatives is presented. Several substitution patterns leading to a high level of stereocontrol have been identified. Axial attack is the preferred reaction pathway for cyclohexyl radicals, and excellent stereoselectivities can be obtained by introducing an axial substitutent at position 2. In this case, a second equatorial substituent ...