Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone

…, A Rapacz, K Pytka, B Filipek, A Siwek, M Cegła…

文献索引：Szkaradek, Natalia; Rapacz, Anna; Pytka, Karolina; Filipek, Barbara; Siwek, Agata; Cegla, Marek; Marona, Henryk Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 514 - 522

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被引用次数: 16

摘要

A series of 9 piperazine derivatives of xanthone were synthesized and evaluated for cardiovascular activity. The following pharmacological experiments were conducted: the binding affinity for adrenoceptors, the influence on the normal electrocardiogram, the effect on the arterial blood pressure and prophylactic antiarrhythmic activity in adrenaline induced model of arrhythmia (rats, iv). Three compounds revealed nanomolar affinity for α1- ...