Vanadium-catalyzed asymmetric oxidation of α-hydroxy esters using molecular oxygen as stoichiometric oxidant

AT Radosevich, C Musich, FD Toste

文献索引：Radosevich, Alexander T.; Musich, Christine; Toste, F. Dean Journal of the American Chemical Society, 2005 , vol. 127, # 4 p. 1090 - 1091

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被引用次数: 157

摘要

A vanadium-catalyzed method for the oxidative kinetic resolution of α-hydroxyesters, using oxygen as the terminal oxidant, is described. The catalyst is generated in situ from vanadium (V) tri-iso-propoxyoxide in combination with a tridentate ligand derived from 3, 5-di-tert- butylsalicylaldehyde and (S)-tert-leucinol. The reaction allows for the enantioselective synthesis of both aromatic and aliphatic secondary alcohols, including those containing ...