Journal of medicinal chemistry

Novel bis [1, 6-dihydro-6, 6-dimethyl-1, 3, 5-triazine-2, 4-diamines] as antitrypanosomal agents

WR Turner, LM Werbel

文献索引：Turner, William R.; Werbel, Leslie M. Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1728 - 1740

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被引用次数: 17

摘要

A series of novel 1, 1'-(4, l-phenylene) bis [1, 6-dihydro-6, 6-dimethyl-1, 3, 5-triazine-2, 4- diamines] was prepared and evaluated for activity against Trypanosoma rhodesiense in mice. The importance of the bis structure and the nature of the spacer between the two phenyl rings for optimal activity have been revealed. The potent parenteral activity of several analogues within this series as well as preliminary indication of oral activity lends ...