Synthetic Communications

SH-methylation of SH-containing heterocycles with dimethyl carbonate via phase-transfer catalytic reaction

…, J Quan, SB Li, Y Zheng, LM Zhu

文献索引：Xie, Jian-Gang; Quan, Jing; Li, Shu-Bai; Zheng, Yan; Zhu, Li-Min Synthetic Communications, 2011 , vol. 41, # 6 p. 871 - 878

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被引用次数: 7

摘要

Abstract A reaction of SH-containing heterocycles with dimethyl carbonate (DMC) in the presence of K2CO3 and tetrabutylammonium bromide (Bu4NBr) gave heteroaryl methyl thioethers in 44–93% yields. The reaction was carried out under mild conditions. This method provided a useful synthetic method for preparation of various heteroaryl methyl thioethers without the use of toxic methylic halides or dimethyl sulfate.