5-Chloro-3-(phenylsulfonyl) indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase

…, SC MacTough, CS Rooney, SK Balani…

文献索引：Williams; Ciccarone; MacTough; Rooney; Balani; Condra; Emini; Goldman; Greenlee; Kauffman; O'Brien; Sardana; Schleif; Theoharides; Anderson Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1291 - 1294

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被引用次数: 201

摘要

Development of effective pharmaceutical interventions in acquired immunodeficiency syndrome (AIDS) is a high priority goal. About 10 million individuals worldwide are estimated to be infected with human immunodeficiency virus (HIV), the causative agent of AIDS, and the number of AIDS-related deaths continues to rise each year. Antiviral therapies which would halt progression of the disease are designed to selectively interfere with the ...