Rhodium (I)??Catalyzed Arylation of β??Chloro Ketones and Related Derivatives through Domino Dehydrochlorination/Conjugate Addition

Q Jiang, T Guo, Q Wang, P Wu…

文献索引：Jiang, Quanbin; Guo, Tenglong; Wang, Qingfu; Wu, Ping; Yu, Zhengkun Advanced Synthesis and Catalysis, 2013 , vol. 355, # 9 p. 1874 - 1880

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被引用次数: 12

摘要

Abstract Highly efficient arylations of β-chloro ketones and their ester and amide derivatives were achieved by means of domino dehydrochlorination/Rh (I)-catalyzed conjugate addition. In situ generated vinyl ketones and their analogues were identified as the reaction intermediates. The present synthetic protocol provides a concise route to (chiral) β-aryl ketones, esters, and amides.

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