Tetrahedron letters

The total synthesis of ritipenems. Construction of penem thiazoline ring by incorporation of two 2C units of glycolic acid.

W Cabri, F Zarini, M D'Anello, M Marchi, A Bedeschi…

文献索引：Cabri; Zarini; D'Anello; Marchi; Bedeschi; Franceschi Tetrahedron Letters, 1993 , vol. 34, # 21 p. 3491 - 3492

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被引用次数: 4

摘要

Abstract Short syntheses of Ritipenem Acoxyl 1a and Ritipenen 1b are reported. The syntheses start from (R)-4-acetoxy-(S)-3 [(R)-1-(t-butyldimethylsilyloxy) ethyl] azetidin-2-one 3 and are based on the incorporation of two 2C units obtained by manipulation of glicolyc acid 4.