Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties

HS Rho, SM Ahn, DS Yoo, MK Kim, DH Cho…

文献索引：Rho, Ho Sik; Ahn, Soo Mi; Yoo, Dae Sung; Kim, Myung Kyoo; Cho, Dong Ha; Cho, Jae Youl Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 22 p. 6569 - 6571

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被引用次数: 32

摘要

This study was conducted to examine the tyrosinase inhibitory and anti-inflammatory activities of kojic acid derivatives. A series of kojic acid derivatives containing thioether, sulfoxide, and sulfone linkages were synthesized. In the tyrosinase assay, kojyl thioether derivatives containing appropriate lipophilic alkyl chains (pentane, hexane, and cyclohexane) showed potent inhibitory activity. However, sulfoxides and sulfones ...