Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives

XK Zhu, J Guan, Z Xiao, LM Cosentino…

文献索引：Zhu, Xiao-Kang; Guan, Jian; Xiao, Zhiyan; Cosentino, L. Mark; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4267 - 4273

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被引用次数: 45

摘要

A series of novel podophyllotoxin derivatives containing structural modifications at C-4 (7– 14), C-4′(16–17), and the methylenedioxy A-ring (23–28) was synthesized and tested for inhibition of HIV replication. Four of these compounds (25–28) were previously reported to show EC50 values of< 0.001 μg/mL and therapeutic index (TI) values> 120. Three of the newly tested compounds (8, 12, and 20) showed good activity with EC50 values of 0.012, ...