Practical Synthesis of N-{4-[(2-Methyl-4, 5-dihydroimidazo [4, 5-d][1] benzazepin-6 (1 H)-yl) carbonyl] phenyl} biphenyl-2-carboxamide Monohydrochloride: an …

T Tsunoda, A Yamazaki, H Iwamoto…

文献索引：Organic Process Research and Development, , vol. 7, # 6 p. 883 - 887

全文：HTML全文

被引用次数: 11

摘要

... Organic Process Research & Development. ... This straightforward process provides a 2-fold increase in the yield of YM087 over the discovery synthesis with respect to ... The key features of this procedure are (1) a reliable imidazole formation from α-bromoketones by controlling the ...