The synthesis and oral antihypertensive activity in conscious spontaneously hypertensive rata of two new series of compounds related to the prototype potassium channel activator cromakalim (1) are described. In the first series, replacement of the benzopyran oxygen atom by nitrogen or methylene led to the 1, 2, 3, 4-tetrahydroquinoline 12 and 1, 2, 3, 4- tetrahydronaphthalene 13, which were both less active than 1. However, in contrast to the ...
