Mechanistic studies on DNA photolyase. 4. The enthalpy of cleavage of a model photodimer

…, AR Dias, A Dhalla, ME Minas da Piedade…

文献索引：Diogo, Herminio P.; Dias, Alberto R.; Dhalla, Adil; Piedade, Manuel E. Minas da; Begley, Tadhg P. Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7340 - 7341

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被引用次数: 27

摘要

Cyclobutane pyrimidine photodimers constitute the highest quantum yield lethal damage caused to DNA by ultraviolet light.'In the cell this lesion can be efficiently repaired by DNA photolyase in a light-dependent reaction (350-450 nm, eq 1).* While model studies using quinones and indoles as sensitizers have demonstrated that both the photodimer radical cation and anion undergo facile fragmentation reaction^,^ the mechanism of this ...