Formal Total Synthesis of Fostriecin by 1, 4??Asymmetric Induction with an Alkyne–Cobalt Complex

Y Hayashi, H Yamaguchi, M Toyoshima…

文献索引：Hayashi, Yujiro; Yamaguchi, Hirofumi; Toyoshima, Maya; Okado, Kotaro; Toyo, Takumi; Shoji, Mitsuru Chemistry - A European Journal, 2010 , vol. 16, # 33 p. 10150 - 10159

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被引用次数: 27

摘要

Abstract The synthesis of a protected dephosphofostriecin, and thereby a formal synthesis of fostriecin, has been accomplished. The synthetic challenges were the construction of four stereogenic centers and the conformationally labile cis-cis-trans-triene moiety. Previous total syntheses have employed at least two asymmetric reactions that required the use of an external chiral auxiliary. Although remote stereoinduction in a 1, 4-relationship is ...