Chemistry and physics of lipids

Drug–phospholipid conjugates as potential prodrugs: synthesis, characterization, and degradation by pancreatic phospholipase A 2

M Kurz, GKE Scriba

文献索引：Kurz, Michael; Scriba, Gerhard K.E Chemistry and Physics of Lipids, 2000 , vol. 107, # 2 p. 143 - 157

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被引用次数: 27

摘要

The aim of the present study was the synthesis of phospholipids containing a drug molecule instead of a fatty acid. Valproic acid and ibuprofen served as model compounds. The target molecules were synthesized either starting from sn-glycero-3-phosphocholine (1) or using (S)-2-O-benzyl-1-O-tritylglycerol (11) and (R)-2-O-benzyl-1-O-tert-butyldiphenylsilylglycerol (12), respectively, as key intermediates. With respect to the surface properties and the ...