New bronchodilators. 1. 1, 5-Substituted 1H-imidazo [4, 5-c] quinolin-4 (5H)-ones

…, T Kuroda, Y Nakasato, H Manabe…

文献索引：Suzuki, Fumio; Kuroda, Takeshi; Nakasato, Yoshisuke; Manabe, Haruhiko; Ohmori, Kenji; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4045 - 4053

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被引用次数: 27

摘要

A series of novel xanthine-based tricyclic heterocycles in lH-imidazo [4, 5-c] quinolin-4 (5H)- ones was designed, synthesized, and tested as potential active bronchodilators. Inhibition of the Schulz-Dale (SD) reaction-induced contraction in trachea and inhibition of antigen inhalation-induced bronchospasm in passively sensitized guinea pigs served as primary in vitro and in vivo assays, respectively. Simultaneous measurement of acute lethal toxicity ( ...