NADH model compounds bearing chiral amide groups have been synthesized. One of these models, 3, possessed the 1, 6-naphtyridinone structure and the key step of its synthesis was a cross coupling reaction which was optimized on the basis of consideration of the mechanism. In this bicyclic model 3, the amide carbonyl dipole is forced in a transoid orientation. In model 1, the free rotation around the C-3-C O amide bond is not hindered ...
