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Effects of α-substitutions on structure and biological activity of anticancer chalcones

NJ Lawrence, RP Patterson, LL Ooi, D Cook…

文献索引:Lawrence, Nicholas J.; Patterson, Richard P.; Ooi, Li-Ling; Cook, Darren; Ducki, Sylvie Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5844 - 5848

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被引用次数: 128

摘要

Chalcones, 1,3-diarylprop-1-enones, are a class of compounds consisting of two aryl rings linked by an α,β-unsaturated ketone moiety. The ease of synthesis of chalcones, from substituted benzaldehydes and acetophenones, makes them an attractive drug scaffold. Some chalcones are natural products found in various plant species around the world and in the last decade or so they have been shown to display a wide range of medicinal properties including antiinflammatory, 1 anti- ...