前往化源商城

举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and biological evaluation of 2-alkoxyphenyl-6-(substituted phenyl)-1, 3, 4-thiadiazole-[3, 2-a]-s-triazin-5, 7-diones and 1-(alkyl and substituted phenyl)-3-[5- …

…, R Pignatello, A Panico, G Mazzone, A Corsaro…

文献索引：Puglisi, Giovanni; Pignatello, Rosario; Panico, Annamaria; Mazzone, Gioacchino; Corsaro, Antonio; et al. European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 277 - 286

全文：HTML全文

被引用次数: 7

摘要

Abstract As an extension of a previous work, in which a series of 2-alkoxyphenyl-6-phenyl-1, 3, 4-thiadiazole-[3, 2-a]-s-triazin-5, 7-diones were synthesized and found to possess analgesic activity, a new series of analogues substituted in the 6-phenyl ring has been prepared and tested with the aim of examining the variations induced by phenyl substituents in biological activity, and thus obtaining useful information about the structure—activity ...

5-(3,4,5-Trimethoxyphenyl)-1,3,4-thiadiazol-2-amine结构式

5-(3,4,5-Trimet...

4-氯苯基异氰酸酯结构式

4-氯苯基异氰酸酯

~77%

6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-chlorophen...

5-(3,4,5-Trimethoxyphenyl)-1,3,4-thiadiazol-2-amine结构式

5-(3,4,5-Trimet...

~%

6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-chlorophen...

4-氯苯基异氰酸酯结构式

4-氯苯基异氰酸酯

~%

6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-chlorophen...

4-氯苯基异氰酸酯结构式

4-氯苯基异氰酸酯

1-(4-chlorophenyl)-3-(5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl)urea结构式

1-(4-chlorophen...

~%

6-(4-chlorophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-chlorophen...

异氰酸4-氟苯酯结构式

异氰酸4-氟苯酯

5-(4-ethoxy-3,5-dimethoxyphenyl)-1,3,4-Thiadiazol-2-amine结构式

5-(4-ethoxy-3,5...

~72%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

异氰酸4-氟苯酯结构式

异氰酸4-氟苯酯

~%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

5-(4-ethoxy-3,5-dimethoxyphenyl)-1,3,4-Thiadiazol-2-amine结构式

5-(4-ethoxy-3,5...

~%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

异氰酸4-氟苯酯结构式

异氰酸4-氟苯酯

1-(5-(4-ethoxy-3,5-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-(4-fluorophenyl)urea结构式

1-(5-(4-ethoxy-...

~%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

5-(2H-1,3-benzodioxol-5-yl)-1,3,4-thiadiazol-2-amine结构式

5-(2H-1,3-benzo...

异氰酸4-氟苯酯结构式

异氰酸4-氟苯酯

~71%

2-(1,3-benzodioxol-5-yl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

5-(2H-1,3-benzodioxol-5-yl)-1,3,4-thiadiazol-2-amine结构式

5-(2H-1,3-benzo...

~%

2-(1,3-benzodioxol-5-yl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

异氰酸4-氟苯酯结构式

异氰酸4-氟苯酯

~%

2-(1,3-benzodioxol-5-yl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

异氰酸4-氟苯酯结构式

异氰酸4-氟苯酯

未登录结构式

~%

2-(1,3-benzodioxol-5-yl)-6-(4-fluorophenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

5-(2H-1,3-benzodioxol-5-yl)-1,3,4-thiadiazol-2-amine结构式

5-(2H-1,3-benzo...

对甲基苯异氰酸酯结构式

对甲基苯异氰酸酯

~70%

2-(1,3-benzodioxol-5-yl)-6-(4-methylphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

对甲基苯异氰酸酯结构式

对甲基苯异氰酸酯

未登录结构式

~%

2-(1,3-benzodioxol-5-yl)-6-(4-methylphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

5-(2H-1,3-benzodioxol-5-yl)-1,3,4-thiadiazol-2-amine结构式

5-(2H-1,3-benzo...

~%

2-(1,3-benzodioxol-5-yl)-6-(4-methylphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

对甲基苯异氰酸酯结构式

对甲基苯异氰酸酯

~%

2-(1,3-benzodioxol-5-yl)-6-(4-methylphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

5-(2H-1,3-benzodioxol-5-yl)-1,3,4-thiadiazol-2-amine结构式

5-(2H-1,3-benzo...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

~74%

2-(1,3-benzodioxol-5-yl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

1-(5-(benzo[d][1,3]dioxol-5-yl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea结构式

1-(5-(benzo[d][...

~%

2-(1,3-benzodioxol-5-yl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

5-(2H-1,3-benzodioxol-5-yl)-1,3,4-thiadiazol-2-amine结构式

5-(2H-1,3-benzo...

~%

2-(1,3-benzodioxol-5-yl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

~%

2-(1,3-benzodioxol-5-yl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(1,3-benzodio...

5-(3,4,5-Trimethoxyphenyl)-1,3,4-thiadiazol-2-amine结构式

5-(3,4,5-Trimet...

4-硝基苯基异氰酸酯结构式

4-硝基苯基异氰酸酯

~61%

6-(4-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-nitropheny...

5-(3,4,5-Trimethoxyphenyl)-1,3,4-thiadiazol-2-amine结构式

5-(3,4,5-Trimet...

~%

6-(4-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-nitropheny...

4-硝基苯基异氰酸酯结构式

4-硝基苯基异氰酸酯

~%

6-(4-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-nitropheny...

4-硝基苯基异氰酸酯结构式

4-硝基苯基异氰酸酯

未登录结构式

~%

6-(4-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-nitropheny...

5-(3,4,5-Trimethoxyphenyl)-1,3,4-thiadiazol-2-amine结构式

5-(3,4,5-Trimet...

对甲基苯异氰酸酯结构式

对甲基苯异氰酸酯

~77%

6-(4-methylphenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-methylphen...

对甲基苯异氰酸酯结构式

对甲基苯异氰酸酯

未登录结构式

~%

6-(4-methylphenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-methylphen...

5-(3,4,5-Trimethoxyphenyl)-1,3,4-thiadiazol-2-amine结构式

5-(3,4,5-Trimet...

~%

6-(4-methylphenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-methylphen...

对甲基苯异氰酸酯结构式

对甲基苯异氰酸酯

~%

6-(4-methylphenyl)-2-(3,4,5-trimethoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

6-(4-methylphen...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

5-(4-ethoxy-3,5-dimethoxyphenyl)-1,3,4-Thiadiazol-2-amine结构式

5-(4-ethoxy-3,5...

~67%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

1-(5-(4-ethoxy-3,5-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea结构式

1-(5-(4-ethoxy-...

~%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

4-甲氧基苯异氰酸酯结构式

4-甲氧基苯异氰酸酯

~%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...

5-(4-ethoxy-3,5-dimethoxyphenyl)-1,3,4-Thiadiazol-2-amine结构式

5-(4-ethoxy-3,5...

~%

2-(4-ethoxy-3,5-dimethoxyphenyl)-6-(4-methoxyphenyl)-[1,3,4]thiadiazolo[3,2-a][1,3,5]triazine-5,7-dione结构式

2-(4-ethoxy-3,5...