Synthesis and antibacterial activity of some novel 1-substituted 1, 4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. Potent antistaphylococcal agents

…, SJ Daum, B Singh, MP Wentland…

文献索引：Reuman, Michael; Daum, Sol J.; Singh, Baldev; Wentland, Mark P.; Perni, Robert B.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2531 - 2540

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被引用次数: 31

摘要

The palladium-catalyzed coupling of 3-and 4-(trialkylstannyl) pyridines with 7-bromo or 7- ChlOrO l-substituted 1, 4-dihydro-4-oxo-3-quinolinecarboxylates has provided access to the corresponding 1-substituted 1, 4-dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic acids. The antibacterial activity of these derivatives was studied with the finding that the optimal 1-and 7- position substituents for Gram positive activity are cyclopropyl and 4-(2, 6- ...