The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

…, BL Pilkington, SE Russell, PA Worthington

文献索引：Hargreaves, Stephanie L.; Pilkington, Brian L.; Russell, Sally E.; Worthington, Paul A. Tetrahedron Letters, 2000 , vol. 41, # 10 p. 1653 - 1656

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被引用次数: 68

摘要

Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross- coupled with 2-(6-bromo-2-pyridyl) pyrimidines in the presence of tetrakis (triphenylphosphine) palladium (0) to produce a series of substituted pyridylpyrimidine fungicides in 32–99% yields.