Tetrahedron

Synthesis and absolute configuration of substituted morpholines

G Bettoni, C Franchini, R Perrone, V Tortorella

文献索引：Bettoni, Giancarlo; Franchini, Carlo; Perrone, Roberto; Tortorella, Vincenzo Tetrahedron, 1980 , vol. 36, p. 409 - 415

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被引用次数: 26

摘要

We studied methods of stereospecific synthesis that enabled us to obtain variously substituted morpholinic compounds and to determine their absolute configuration. From a study of the chiroptical properties of synthetic N-[2-pyridyl-N-oxide] derivatives of optically active morpholines, it was possible to correlate the sign of the Cotton effect with the absolute configuration. This correlation agrees with that previously established for derivatives of the ...