Synthesis of deuterium labelled diclofenac with improved isotopic enrichment

K Wu, L Tian, H Li, J Li, L Chen

文献索引：Keying, Wu; Lei, Tian; Hongye, Li; Jian, Li; Liqin, Chen Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 13 p. 535 - 537

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被引用次数: 1

摘要

Abstract A five-step synthesis of deuterium-labelled diclofenac starting from 2-phenyl [2 H 5] acetic acid is described. The synthesis prevents deuterium from scrambling during the reaction. It offers the labelled compound with over 99% isotopic enrichment. It also provides a possible alternative route for the synthesis of deuterium-labelled 4′-hydroxydiclofenac, which is the principal human metabolite of diclofenac. Copyright© 2009 John Wiley & ...