Abstract Pyrazines and quinoxalines bearing 2-substituents that direct ortho metalation reacted with lithium 2, 2, 6, 6-tetramethylpiperidide to produce 2-substituted-3- lithiopyrazines and quinoxalines. These lithio reagents reacted with N-methoxy-N- methylbenzamide to give good to moderate yields of 3-substituted pyrazinyl or quinoxalinylphenylmethanones. The 3-methylthio substituents of some ketone products ...
