Design, synthesis and biological evaluation of benzopyran derivatives as KATP channel openers

…, H Zhang, H Gao, W Huang, X Zhu, S Ni…

文献索引：Zhou, Jinpei; Qian, Hai; Zhang, Huibin; Gao, Hui; Huang, Wenlong; Zhu, Xiaoyun; Ni, Shuaijian; Zhang, Chuntao Letters in Drug Design and Discovery, 2010 , vol. 7, # 6 p. 415 - 420

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被引用次数: 2

摘要

In order to complete the SAR and discover new potent and selective PCOs, some changes were made to the C-4 and C-2 substitutions of cromakalim. A series of 4-amino acid substituted-2, 2-dialkylchromans structurally related to cromakalim were synthesized and evaluated, as ATP-sensitive potassium channel openers (8a-l). Preliminary biological tests suggested that these compounds exhibited potent to mild relaxation activity of the KCl- ...