Discovery of 1-[4-(N-benzylamino) phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP) 1 inhibitors

M Uno, Y Koma, HS Ban, H Nakamura

文献索引：Uno, Masaharu; Koma, Yosuke; Ban, Hyun Seung; Nakamura, Hiroyuki Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 16 p. 5169 - 5173

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被引用次数: 13

摘要

We developed 1-[4-(N-benzylamino) phenyl]-3-phenylurea derivative 4 (GN6958) as a non- peptidic selective SUMO-sentrin specific protease (SENP) 1 protease inhibitor based on the hypoxia inducible factor (HIF)-1α inhibitor 1 (GN6767). The direct interaction of compound 1 with SENP1 protein in cells was observed by the pull-down experiments using the biotin- tagged compound 2 coated on the streptavidin affinity column. Among the various 1-[4-(N- ...