Synthesis and radioprotective activity of 2-phenylethylamine derivatives

TV Alpatova, VY Kovtun, ZA Olovyanishnikova…

文献索引：Alpatova, T. V.; Kovtun, V. Yu.; Olovyanishnikova, Z. A.; Klimova, A. D.; Kulinskii, V. N.; Yashunskii, V. G. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 11 p. 857 - 863 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 11 p. 1349 - 1355

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摘要

We chose the corresponding chlorides (V-VII) as the starting materials, since it has been reported [6] that the hydroxyl group at the~-position of amine (IV) is readily replaced by chlorine by the action of SOCI 2. It has been also reported [8] that during the substitution of the OH group by halogen in compounds with phenolic hydroxyls, the latter have to be protected by an acyl group. However, the hydrochloride of (III), similarly as that of IV, ...