Synthesis and biological activities of 4-substituted pyrrolo [2, 3-a] carbazole Pim kinase inhibitors

…, L Nauton, N Candelon, E Debiton, V Théry…

文献索引：Giraud, Francis; Akue-Gedu, Rufine; Nauton, Lionel; Candelon, Nicolas; Debiton, Eric; Thery, Vincent; Anizon, Fabrice; Moreau, Pascale European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 225 - 236

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被引用次数: 13

摘要

Pyrrolo [2, 3-a] carbazole-3-carbaldehydes are potent Pim kinase inhibitors with in vitro antiproliferative activities. In the present study, we report the synthesis and biological activities (Pim kinase inhibition and in vitro antiproliferative potency) of new 4-substituted pyrrolo [2, 3-a] carbazoles. The results demonstrated that the Pim kinase inhibitory potency (especially Pim-3) can be conserved for pyrrolo [2, 3-a] carbazoles bearing a ...