Synthesis of lipopolyhydroxylalkyleneamines for gene delivery

…, G Zhang, J Marhefka, MV Kameneva, D Liu

文献索引：Li, Qun; Zhang, Guisheng; Marhefka, Joie; Kameneva, Marina V.; Liu, Dexi Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2428 - 2432

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被引用次数: 2

摘要

Various bis (2-hydroxy-3-chloropropyl) alkylamines were synthesized by coupling primary amine with epichlorohydrin and utilized as a monomer to react with ethylenediamine (EDA), N, N′-dimethylethylenediamine (DMEDA), or tetramethylethylenediamine (TMEDA) to generate a series of lipopolyhydroxylalkyleneamines. The number-and weight-average molecular weight (Mn and Mw) and polydispersity index (Mw/Mn) of the ...