Abstract Three series of new trifluoromethyl substituted quinolone derivatives were synthesized (4a–f, 6a–f and 8a–f) from corresponding substituted anilines by multi-step reactions. The regioselective alkylation with different alkyl halides were carried out by approaching two different routes to get the final products in good yield. Newly synthesized compounds were characterized by spectral study and also by C, H, N analyses. Three ...