Synthesis and anti-inflammatory activity of 21-thio derivatives of corticosteroids

…, AL Mikhalchuk, VA Khripach, BV Kuz'mitskii…

文献索引：Pshenitskii, V. N.; Mikhalchuk, A. L.; Khripach, V. A.; Kuz'mitskii, B. V.; Mzulo, N. A.; Shafranskaya, G. A. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 3 p. 225 - 229 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 3 p. 307 - 311

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摘要

The structure of 21-thio derivatives of corticosteroids IX was confirmed by the data of elementary analysis, L~, IR and PMR spectra. In the IR spectra of compounds IX, there are absorption bandsin the regions of 1600-1620 cm-*(4-C= C), 1630~ 1680 cm-I (3-C= C), and 1690-1725 cm-I (20-C= C). In the spectra of acids I-VI there are also absorption bands in the regions of 1710-1740 cm-~(CO of the carboxylic group) and 2400-3300 cm-~(OH of the ...