The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives

…, DJ Carini, GB Gregory, AL Johnson…

文献索引：Duncia, John V.; Chiu, Andrew T.; Carini, David J.; Gregory, George B.; Johnson, Alexander L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1312 - 1329

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被引用次数: 264

摘要

A new class of potent antihypertensives has been discovered that exert their effect through blockade of the angiotensin I1 (AII) receptor. Most AII antagonists reported 80 far are peptide mimics of the endogenous vasoconstrictor octapeptide angiotensin 11. The compounds of this paper are nonpeptides and therefore constitute a new class of potent AI1 receptor antagonists. Based on the overlap of a conformation of AI1 with literature lead 3, a ...