Novel quinuclidine-based ligands for the muscarinic cholinergic receptor

J Saunders, M Cassidy, SB Freedman…

文献索引：Saunders, John; Cassidy, Mark; Freedman, Stephen B.; Harley, Elizabeth A.; Iversen, Leslie L.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1128 - 1138

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被引用次数: 168

摘要

Recent clinical studies on Alzheimer's patients have implied that only agents displaying high efficacy at the cortical muscarinic receptor have yielded encouraging results. This paper describes the design, synthesis, and biochemical characterization of novel quinuclidine- based muscarinic agonists which can readily penetrate into the central nervous system and which are capable of displaying high efficacy at cortical sites. With use of a biochemical ...