A facile synthesis of 3??amino??5??substitutedaminoisothiazole??4??carboxylic acid derivatives

CJ Shishoo, MB Devani, S Ananthan…

文献索引：Shishoo, C. J.; Devani, M. B.; Ananthan, S.; Bhadti, V. S.; Ullas, G. V. Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 2 p. 759 - 765

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被引用次数: 6

摘要

762 С. J. Shishoo, M. В. Devani, S. Ananthan, VS Bhadti and GV Ullas Vol. 25 employed, except that the mixture of sodium ethoxide, ethyl cyanoace- tate and methyl isothiocyanate was refluxed for 10 minutes, allowed to cool and stirred at room temperature for 12 hours before being reacted with chloramine. Recrystallization of the crude product from ethanol af- forded 3.0 g (60%) of 6b as colorless crystals, mp 145-147°; ir (Nujol): 3500, 3360, 3300, 3180 (NH), 1680, ...