Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization
…, C Henn, JC de Jong, C Zimmer, B Kirsch…
文献索引：Lu, Cenbin; Kirsch, Benjamin; Zimmer, Christina; De Jong, Johannes C.; Henn, Claudia; Maurer, Christine K.; Muesken, Mathias; Haeussler, Susanne; Steinbach, Anke; Hartmann, Rolf W. Chemistry and Biology, 2012 , vol. 19, # 3 p. 381 - 390
The Gram-negative pathogen Pseudomonas aeruginosa produces an intercellular alkyl quinolone signaling molecule, the Pseudomonas quinolone signal. The pqs quorum sensing communication system that is characteristic for P. aeruginosa regulates the production of virulence factors. Therefore, we consider the pqs system a novel target to limit P. aeruginosa pathogenicity. Here, we present small molecules targeting a key player of ...
