Aromatic bisabolene derivatives were prepared by two methods involving cross-coupling of organozinc reagents. The first synthesis of (±)-glandulone A (10), as well as syntheses of (±)- curcuhydroquinone (8) and (±)-curcuquinone (9), were accomplished via coupling of a secondary alkyl zinc reagent (1, 5-dimethyl-4-hexenylzinc halide, 18) to protected bromohydroquinones using Pd (dppf) Cl2 as catalyst. Coupling of arylzinc halides with ...
