Application of the message-address concept in the design of highly potent and selective non-peptide. delta. opioid receptor antagonists

PS Portoghese, M Sultana, H Nagase…

文献索引：Portoghese; Sultana; Nagase; Takemori Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 281 - 282

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被引用次数: 256

摘要

Progress in medicinal chemistry relies heavily on ligands as pharmacologic tools to evaluate selectivity of action. This is particularly relevant to opioid receptors, as there are at least three major receptor types (p, K, 6) that modulate a variety of physiologic pr0cesses. l Although highly selective opioid antagonists have been reported for p2, 3 and K~ receptors, the fact that antagonist ligands for 6 receptors are peptides5 related to enkephalin limits ...