J. Med. Chem. 1992, 35,687-694 687 are the mean and standard error of at least three determinations. In Vivo Characterization. The writhing test was performed using male albino mice (Charles River Laboratories, CD-l/HAM/lLR) weighing between 20 and 30 g. Twenty- five minutes after sc administration of the teat compound (0.1 mL/lO g body weight), 0.025%(w/v) phenylbenzoquinone was injected intraperitoneally (0.1 mL/g body weight). ...
