Synthesis of ethyl 2??[(1??aryl??1H??1, 2, 4??triazol??3??yl) oxy] propionates and related derivatives

JR Beck, GE Babbitt, MP Lynch

文献索引：Beck, James R.; Babbitt, George E.; Lynch, Michael P. Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1467 - 1470

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被引用次数: 4

摘要

Abstract Alkylation of 1-aryl-1H-1, 2, 4-triazol-3-ols with ethyl 2-bromopropionate under basic conditions resulted in the formation of 2-[(1-aryl-1H-1, 2, 4-triazol-3-yl) oxy] propionic acid, ethyl esters. No N-alkylated products were detected. Similar alkylation of 2-oxo-5- phenyl-1, 3, 4-thiazole and the corresponding 1, 3, 4-oxadiazole gave only N-alkylated derivatives. With 4-hydroxy-6-phenylpyrimidine and 2-oxo-4-phenylthiazole, both O-and N ...