On the meaning of affinity: cluster glycoside effects and concanavalin A

…, SA McMahon, DN Moothoo, JH Naismith…

文献索引：Dimick, Sarah M.; Powell, Steven C.; McMahon, Stephen A.; Moothoo, Davina N.; Naismith, James H.; Toone, Eric J. Journal of the American Chemical Society, 1999 , vol. 121, # 44 p. 10286 - 10296

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被引用次数: 219

摘要

The inhibition of protein-carbohydrate interaction provides a powerful therapeutic strategy for the treatment of myriad human diseases. To date, application of such approaches have been frustrated by the inherent low affinity of carbohydrate ligands for their protein receptors. Because lectins typically exist in multimeric assemblies, a variety of polyvalent saccharide ligands have been prepared in the search for high affinity. The cluster glycoside effect, or ...