Substituted benzopyranobenzothiazinones. Synthesis and estrogenic activity on MCF-7 breast carcinoma cells

Y Jacquot, L Bermont, H Giorgi, B Refouvelet…

文献索引：Jacquot, Yves; Bermont, Laurent; Giorgi, Herve; Refouvelet, Bernard; Adessi, Gerard L; Daubrosse, Edwige; Xicluna, Alain European Journal of Medicinal Chemistry, 2001 , vol. 36, # 2 p. 127 - 136

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被引用次数: 35

摘要

In the search for new agents with estrogenic activity mediated by estrogen receptors (ER), six 6, 12-dihydro-1-benzopyrano [3, 4-b][1, 4] benzothiazin-6-ones 3a–f were synthesized. These compounds were readily prepared by the addition of 2-aminothiophenol 2 to substituted 4-hydroxycoumarin derivatives 1a–e. The estrogenic effect has been evaluated on the proliferation of MCF-7 breast adenocarcinoma cells and the specificity of described ...