Features and Applications of [Rh (CO) 2Cl] 2-Catalyzed Alkylations of Unsymmetrical Allylic Substrates

BL Ashfeld, KA Miller, AJ Smith, K Tran…

文献索引：Ashfeld, Brandon L.; Miller, Kenneth A.; Smith, Anna J.; Tran, Kristy; Martin, Stephen F. Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9018 - 9031

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被引用次数: 30

摘要

A novel regio-and stereoselective [Rh (CO) 2Cl] 2-catalyzed allylic alkylation of unsymmetrical allylic carbonates was discovered. The regioselectivity of the reaction favors product ratios in which substitution occurs at the carbon bearing the leaving group. When an enantiomerically enriched carbonate (≥ 99% ee) was examined, the Rh (I)-catalyzed allylic alkylation proceeded stereoselectively to provide the alkylation product with retention of ...