Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents

MH Norman, GC Rigdon, F Navas III…

文献索引：Norman, Mark H.; Rigdon, Greg C.; Navas, Frank; Cooper, Barrett R. Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2552 - 2563

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被引用次数: 59

摘要

Schizophrenia has been referred to as the “cancer” of the mental i1lnesses. l The vast amount of research directed toward the treatment of schizophrenia in recent years attests to the inadequacy of current methods of treatment and the need for new and improved therapeutic agent~.~ b Several neuroleptic drugs are clinically available to treat this devastating mental disorder; however, each of these agents has its shortcomings. ...