Bioorganic & medicinal chemistry letters

Design and synthesis of 3-pyrazolyl-thiophene, thieno [2, 3-d] pyrimidines as new bioactive and pharmacological activities

HN Hafez, ABA El-Gazzar

文献索引：Hafez; El-Gazzar Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5222 - 5227

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被引用次数: 67

摘要

Two series of 5-ethyl-2-amino-3-pyrazolyl-4-methylthiophenecarboxylate and 2-thioxo-N3- aminothieno [2, 3-d] pyrimidines were prepared from 3, 5-diethyl-2-amino-4-methylthio- phenecaboxylate and evaluated as anti-inflammatory, analgesic and ulcerogenic activities. Among the compounds studied, compounds which containing the substituted hydrazide at C- 3 position 7, 16, and 17a showed more potent anti-inflammatory and analgesic activities ...