Diastereocontrolled synthesis of pyrrolidines by nickel promoted tandem cyclization-quenching of aminobromodienes
…, M Martínez, A Llebaria, JM Moretó, A Delgado
文献索引：Cancho, Yolanda; Martin, Joan M.; Martinez, Maria; Llebaria, Amadeu; Moreto, Josep M.; Delgado, Antonio Tetrahedron, 1998 , vol. 54, # 7 p. 1221 - 1232
The nickel promoted tandem cyclization-quenching of tethered aminobromodienes has been extended to the synthesis of 2, 3, 4-trisubstituted pyrrolidines. By a judicious choice of substituents on the starting aminohalodiene, the diastereoselectivity of the process can be efficiently controlled. When a chiral auxiliary on the nitrogen atom is used, enantiomerically enriched pyrrolidines can be obtained after removal of the auxiliary.
