Catalytic recruitment by phosphonyl derivatives as inactivators of acetylcholinesterase and substrates for imidazole-catalyzed hydrolysis:. beta.-deuterium isotope …
AJ Bennet, IM Kovach, JA Bibbs
文献索引：Bennet, Andrew J.; Kovach, Ildiko M.; Bibbs, Jeffrey A. Journal of the American Chemical Society, 1989 , vol. 111, # 16 p. 6424 - 6427
Abstract:@-Deuterium secondary isotope effects for the phosphonylation of the active site serine of acetylcholinesterase (AChE) by phosphonyl derivatives at 25 OC and pH 7.70 in 0.05 M phosphate buffer were as follows: 3, 3-dimethyl-2-butyl methylphosphonofluoridate (soman), 0.90* 0.03; 2-propyl methylphosphonofluoridate (sarin), 0.91 f 0.04; 4-nitrophenyl2- propyl methylphosphonate (IMN), 0.93* 0.05.@-Deuterium isotope effects for the ...
