Transnitrosation of alicyclic N-nitrosamines containing a sulfur atom

…, S Kondo, Y Ono, C Saso, M Mochizuki

文献索引：Inami, Keiko; Kondo, Sonoe; Ono, Yuta; Saso, Chiharu; Mochizuki, Masataka Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7853 - 7857

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被引用次数: 4

摘要

Abstract Aromatic and aliphatic nitrosamines are known to transfer a nitrosonium ion to another amine. The transnitrosation of alicyclic N-nitroso compounds generates S- nitrosothiols, which are potential nitric oxide donors in vivo. In this study, certain alicyclic N- nitroso compounds based on non-mutagenic N-nitrosoproline or N-nitrosothioproline were synthesised, and the formation of S-nitrosoglutathione (GSNO) was quantified under ...