Tetrahedron

The preparation of 4-and 6-chloro-2-chloromethylpyridine

JH Barnes, FR Hartley, CEL Jones

文献索引：Barnes, John H.; Hartley, Frank R.; Jones, Christopher E. L. Tetrahedron, 1982 , vol. 38, # 22 p. 3277 - 3280

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被引用次数: 16

摘要

6-Chloro-2-chloromethylpyridine is prepared from 6-chloro-2-methylpyridine by a route in which the 2-Me substituent was successively converted to 2-acetoxymethyl, 2-hydroxymethyl and finally to the required 2-chloromethyl substituent. Attempts to simultaneously monochlorinate the Me group and reduce the N-oxide function of 6-chloro-2-methylpyridine- N-oxide with methanesulphonyl chloride and p-toluenesulphonyl chloride gave only very ...